A first-time mother dog might ignore her puppies due to a lack of experience. You can try placing the puppies in front of the mother dog, particularly when they're trying to nurse. This might trigger her maternal instincts and encourage her to care for them. Another reason could be a lack of milk production. In this case, you should supplement her diet to increase her milk supply. If the mother dog is actively rejecting nursing, you can use puppy milk replacer or consider fostering the puppies to another nursing dog.

What to Do if a Mother Dog Ignores Her Puppies
1. If the mother dog seems inexperienced, place the puppies near her, especially when they want to nurse. This may awaken her maternal instincts, turning her into a nurturing mother. The sight of her puppies seeking milk might trigger her natural caregiving response. This is a critical step to encourage her to bond with her pups.
2. If the mother dog refuses to nurse, pet owners can purchase special puppy formula from pet stores and bottle-feed the puppies. This ensures they receive the necessary nutrition if their mother won't nurse. It's important to follow the feeding instructions on the formula to meet the puppy's needs.
3. You could consider giving the puppies to another nursing mother dog. If the puppies carry the scent of the new mother's own biological offspring, or are marked with her urine, she is more likely to accept and nurse them. This utilizes the natural maternal instinct of a lactating dog.
4. Sometimes, a mother dog might not nurse due to insufficient milk production. Increase her nutrient intake, especially foods known to aid lactation, and gently massage her mammary glands to help with milk production. A vet can advise on proper diet and supplements.
Important Tips for Hand-Rearing Puppies
1. Use a high-quality puppy milk replacer, preferably a goat milk-based formula. Because puppies are unable to nurse by themselves, pet owners will need to buy bottles to feed them. Begin with small amounts to avoid digestive upset in puppies. Overfeeding can cause diarrhea, so it's important to monitor how much they are eating.
2. Avoid feeding cow's milk to puppies. It has larger molecules than goat's milk and is often difficult for young pups to digest due to their sensitive digestive systems. Cow's milk also contains higher protein levels which could trigger allergies and even be life-threatening to some puppies. Goat milk is generally considered gentler on puppies’ stomachs and easier to digest. Always consult a vet on the best food options for your newborn pups.